GETTING MY NR1-SITE TO WORK

Making use of this tactic, Kalbaugh et al. assigned affinity and efficacy roles to positions inside the LBDs with the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with bound ligand impacted the two efficacy and affinity, when positions that stabilize the shut cleft conformation without having a immediate ligand conver